Jae Yong Yoo, Bo Hwa Son, Wahyu Indra Fanata, Rikno Harmoko, Ki Seong Ko, Nirmal Kumar Ramasamy, Thiyagarajan Thulasinathan, Kyung Hwa Kim, Sang Yeol Lee, Kyun Oh Lee
언어
영어(ENG)
URL
https://www.earticle.net/Article/A192893
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원문정보
초록
영어
Environmental or physiological influences that induce accumulation of unfolded proteins in the lumen of endoplasmic reticulum (ER) cause ER stress and activate signaling pathway called unfolded protein response (UPR). An ER-located transmembrane receptor protein kinase/ribonuclease called Ire1 plays an essential role in the UPR in yeasts and mammals. However, it has been unclear whether a similar mechanism is applicable to Arabidopsis. To elucidate the role of Arabidopsis IRE1, we performed functional analyses by isolating loss-of-function mutants of IRE1A and IRE1B. We found that a double mutant of Arabidopsis IRE1A and IRE1B (ire1a/ire1b) is more sensitive to the ER stress inducer tunicamycin than the wild-type. ire1a/ire1b result in a delayed induction of BiP3 which is well known ER chaperone by DTT treatment, whereas induction of BiP1 in ire1a/ire1b was similar with that of WT. Our result indicate that IRE1A and IRE1B are implicated in unfolded protein response signaling in plants.
저자
Jae Yong Yoo [ Division of Applied Life Science (BK21 Program) and PMBBRC, Gyeongsang National University ]
Bo Hwa Son [ Division of Applied Life Science (BK21 Program) and PMBBRC, Gyeongsang National University ]
Wahyu Indra Fanata [ Division of Applied Life Science (BK21 Program) and PMBBRC, Gyeongsang National University ]
Rikno Harmoko [ Division of Applied Life Science (BK21 Program) and PMBBRC, Gyeongsang National University ]
Ki Seong Ko [ Division of Applied Life Science (BK21 Program) and PMBBRC, Gyeongsang National University ]
Nirmal Kumar Ramasamy [ Division of Applied Life Science (BK21 Program) and PMBBRC, Gyeongsang National University ]
Thiyagarajan Thulasinathan [ Division of Applied Life Science (BK21 Program) and PMBBRC, Gyeongsang National University ]
Kyung Hwa Kim [ Division of Applied Life Science (BK21 Program) and PMBBRC, Gyeongsang National University ]
Sang Yeol Lee [ Division of Applied Life Science (BK21 Program) and PMBBRC, Gyeongsang National University ]
Kyun Oh Lee [ Division of Applied Life Science (BK21 Program) and PMBBRC, Gyeongsang National University ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.