Earticle

초록

영어

Enterovirus 71 (EV71) is a major causative agent of hand-foot-and-mouth disease (HFMD). The clinical severity of EV71central nerve system (CNS) infection is mostly in children less than 5 years-old. Recently, the twoglycosylated membrane proteins SCARB2 and PSGL-1 have been identifiedas the cellular and functional receptors of EV71.But the role of glycosylation in EV71 infection remainsunclear. In this study, we demonstrated thatthe attachment of EV71 to two susceptible cell lines werediminished after the removal of cell surface sialic acids. Pre-incubatecells with sialic acid specific lectins, MAA and SNA,reducedthe binding of EV71. Additionally, we found that SCARB2 was a sialylated glycoprotein,andthe interaction of SCARB2and EV71was decreased after desialylation. Based on these results, we concluded that the attachment of EV71 to cell surface was assisted bysialic acids.Cell surface sialylation should be a key regulator that facilitates the binding and infection of EV71.

저자

• Pei-Yi Su [ Institute ofBasic Medical Sciences, Center of Infectious Disease and Signaling Research, National Cheng Kung University,Tainan, Taiwan ]
• Yueh-Tung Liu [ Department of Medical Laboratory Science and Biotechnology, Blood Bank, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan ]
• Chuan-Fa Chang [ Department of Medical Laboratory Science and Biotechnology, Institute of Basic Medical Sciences, Center of Infectious Disease and Signaling Research, National Cheng Kung University,Tainan, Taiwan ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국당과학회 학술대회

• 간기

  연간

• 수록기간

  2006~2022

• 십진분류

  KDC 517 DDC 614