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Recent Progress on Skin-Derived Mesenchymal Stem Cells in Pigs

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Reproductive & developmental biology 바로가기
  • 통권
    Volume 36 No 4 (2012.12)바로가기
  • 페이지
    pp.283-290
  • 저자
    B. Mohana Kumar, Rajreddy Patil, Sung-Lim Lee, Gyu-Jin Rho
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A192769

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초록

영어
Skin serves as an easily accessible source of multipotent stem cells with potential for cellular therapies. In pigs, stem cells from skin tissues of fetal and adult origins have been demonstrated as either floating spheres (cell aggregates) or adherent spindle-shaped mesenchymal stem cell (MSC)-like cells depending on culture conditions. The cells isolated from the epidermis and dermis of porcine skin showed plastic adherent growth in the presence of serum and positively expressed a range of surface and intracellular markers that are considered to be specific for MSCs. The properties of primitive stem cells have been observed with the expression of alkaline phosphatase and markers related to pluripotency. Further, studies have shown the ability of skin-derived MSCs to differentiate in vitro along mesodermal, neuronal and germ-line lineages. Moreover, preclinical studies have also been performed to assess their in vivo potential, and the findings appear to be effective in tissue regeneration at the defected site after transplantation. The present review describes the recent progress on the biological features of porcine skin-derived MSCs as adherent cells, and summarizes their potential in advancing stem cell based therapies.

목차

ABSTRACT
 INTRODUCTION
  PHENOTYPIC CHARACTERIZATION, ALKALINEPHOSPHATASE (AP) ACTIVITY AND EXPRESSION OF PLURIPOTENT MARKERS
  ISOLATION, CULTURE AND EXPANSION POTENTIAL
 IN VITRO MULTILINEAGE DIFFERENTIATION POTENTIAL
  Osteogenic Differentiation
  Adipogenic Differentiation
  Chondrogenic Differentiation
  Neural Differentiation
  Differentiation into Oocyte-Like Cells (OLCs)
  Potential of Skin-Derived MSCs for Therapeutic Applications
  Conclusions and Future Research
 REFERENCES

키워드

Skin Mesenchymal stem cells Adherent cells Differentiation Pig

저자

  • B. Mohana Kumar [ Department of OBS/Theriogenology and Biotechnology, College of Veterinary Medicine, ]
  • Rajreddy Patil [ Department of OBS/Theriogenology and Biotechnology, College of Veterinary Medicine, ]
  • Sung-Lim Lee [ Department of OBS/Theriogenology and Biotechnology, College of Veterinary Medicine, ]
  • Gyu-Jin Rho [ Department of OBS/Theriogenology and Biotechnology, College of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju 660-701, Korea ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Reproductive & developmental biology
  • 간기
    계간
  • pISSN
    1738-2432
  • eISSN
    2288-0151
  • 수록기간
    1977~2018
  • 십진분류
    KDC 527 DDC 636

이 권호 내 다른 논문 / Reproductive & developmental biology Volume 36 No 4

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