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Suppressive Effects of Anthocyanins on Athma-specific T-helper 2 Cytokine Expression and β-Hexosaminidase Release in IgE-Antigen Complex-Stimulated RBL-2H3 Cells

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2011 한국당과학회 하계 학술대회 (2011.06)바로가기
  • 페이지
    pp.48-49
  • 저자
    Mi Ja Chung, Woo Jung Kim, Seong Jae Jang, Ju Hee Ko, Doo Jin Choi, Ha Na Choi, Ji Sun Lee, Yong Il Park
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A192692

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원문정보

초록

영어
Anthocyanins belong to a group of flavonoid compounds and are well known for their various health beneficial effects including antioxidative activities. Among them, the major anthocyanins isolated from the seed coat of black soybean (Glycine max L.) were previously characterized as glycosides having glucopyranose. Asthma is an allergic disease that is strongly associated with various immune cells including basophils and mast cells. Eosinophils, basophils and mast cells play important roles in asthma through the release of inflammatory mediators such as athma-specific T-helper (Th)2 cytokines and subsequent amplification of asthma symptoms by their degranulation. Rat basophilic leukemia RBL-2H3 cells was the most common in vitro models used for evaluating asthmatic reactions. We examined the effects of anthocyanin from the seed coat of black soybean (Glycine max L.) on the antigen-stimulated degranulation and Th2 cytokines production in RBL-2H3. Cell degranulation was evaluated by detecting the release of β -hexosaminidase. The β-hexosaminidase release and Th2 cytokine production in RBL-2H3 cells upon stimulation with IgE-antigen complex was much higher those that in untreated control cells. Anthocyanins significantly suppressed the IgE-antigen complex-induced degranulation of RBL-2H3 and inhibited IgE-antigen complex-mediated interleukin (IL)-4, IL-13 and TNF-α production in RBL-2H3 cells. These findings suggest that anthocyanins from the seed coat of black soybean (Glycine max L.) effectively inhibit asthmatic reactions and may have beneficial effects against allergic asthma.

저자

  • Mi Ja Chung [ Department of Biotechnology, The Catholic University of Korea, Bucheon ]
  • Woo Jung Kim [ Department of Biotechnology, The Catholic University of Korea, Bucheon ]
  • Seong Jae Jang [ Department of Biotechnology, The Catholic University of Korea, Bucheon ]
  • Ju Hee Ko [ Department of Biotechnology, The Catholic University of Korea, Bucheon ]
  • Doo Jin Choi [ Department of Biotechnology, The Catholic University of Korea, Bucheon ]
  • Ha Na Choi [ Department of Biotechnology, The Catholic University of Korea, Bucheon ]
  • Ji Sun Lee [ Department of Biotechnology, The Catholic University of Korea, Bucheon ]
  • Yong Il Park [ Department of Biotechnology, The Catholic University of Korea, Bucheon ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

이 권호 내 다른 논문 / 한국당과학회 학술대회 2011 한국당과학회 하계 학술대회

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