Ganglioside are ubiquitous membrane component in mammalian cells and suggested to play important roles in various cell functions such as cell-cell recognition, differentiation and transmembrane signaling. These compounds are localized in a glycosphingolipid-enriched microdomain on the cell surface and regulated by the glycosphingolipid composition. However, the role that gangliosides play in the adhesive interaction response by xenotransplantation is not yet clearly understood. In this study, we investigated expression patterns of gangliosides in tight contact between human umbilical vein endothelial cells (HUVECs) and micro-pig aortic endothelial cells (MPAECs). Analysis of ganglioside expression pattern showed that differential expression patterns of ganglioside in tight contact between HUVECs and MPAECs. Furthermore, we confirmed that cell adhesion molecule expression in tight contact between HUVECs and MPAECs. Taken together, these results suggested that differential expression of gangliosides in tight contact between HUVECs and MPAECs may play a role in adhesive interaction response in successful clinical xenotransplantation.
저자
So-Dam Lee [ Department of Biological Science, College of Natural Sciences, Wonkwang University ]
Dong-Hoon Kwak [ Department of Biological Science, College of Natural Sciences, Wonkwang University ]
Young-Choon Lee [ Department of Biotechnology, Dong-A University, Busan ]
Keon-Bong Oh [ National institute of Animal Science Rural Development Administration, Animal Biotechnology Division ]
Hwi-Cheul Lee [ National institute of Animal Science Rural Development Administration, Animal Biotechnology Division ]
Ji-Su Kim [ National Primate Research Center (NPRC), Korea Research Institute of Bioscience & Biotechnology, Ochang, Chungbuk 363-883, Korea. ]
Byoung-Boo Seo [ Department of Animal Resources, Collage of Life & Environmental Science, Daegu University ]
Jae-Sung Ryu [ Department of Biological Science, College of Natural Sciences, Wonkwang University ]
So-Hyun Lee [ Department of Biological Science, College of Natural Sciences, Wonkwang University ]
Ju-Taek Lee [ Department of Biological Science, College of Natural Sciences, Wonkwang University ]
Yoon-Ju Na [ Department of Biological Science, College of Natural Sciences, Wonkwang University ]
Su-Bin Lee [ Department of Biological Science, College of Natural Sciences, Wonkwang University ]
Kyu-Tae Chang [ National Primate Research Center (NPRC), Korea Research Institute of Bioscience & Biotechnology, Ochang ]
Young-Kug Choo [ Department of Biological Science, College of Natural Sciences, Wonkwang University ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.