Earticle

초록

영어

Every cell in an organism synthesizes a heterogeneous array of glycans in the form of various structures. Cell surface glycosylation may play an important role in development and may provide important new sources of markers for differentiation. However, studies regarding the glycosylation of cell surfaces are limited due to the lack of sensitive analytical methods. A mass spectrometry-based method that enables specific detection and quantitation, and acquisition of structural information has been developed. We have mapped cell surface glycans from more than 30 human cell lines including embryonic stem cells, cancer cells, and somatic cell lines. The results represent that specific surface glycomic signatures might have functional implications as well as characteristic features of a specific cell type.

저자

• Hyun Joo An [ Graduate School of Analytical Science and Technology, ChungNam National University, Cancer Research Institute, ChungNam National University, Daejeon, South Korea ]
• Mary Saunders [ University of California, Medical School, Sacramento, CA, USA ]
• Shuai Wu [ Department of Chemistry, University of California, Davis, CA, USA ]
• Jaehan Kim [ Department of Food Nutrition, ChungNam National University, Daejeon, South Korea ]
• Lauren Dimapasoc [ Department of Chemistry, University of California, Davis, CA, USA ]
• Kit S. Lam [ University of California, Medical School, Sacramento, CA, USA ]
• Carlito B. Lebirlla [ Department of Chemistry, University of California, Davis, CA, USA ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국당과학회 학술대회

• 간기

  연간

• 수록기간

  2006~2022

• 십진분류

  KDC 517 DDC 614