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Roles of GQ1b on the learning and memory via NMDA receptor and BDNF/TrkB signaling pathway of rats
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- 발행기관
- 한국당과학회 바로가기
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- 간행물
- 한국당과학회 학술대회 바로가기
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- 통권
- 2011 한국당과학회 동계 학술대회 (2011.01)바로가기
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- 페이지
- pp.73-74
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A192641
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원문정보
초록
- 영어
- GQ1b is a tetrasialo-ganglioside that has four sialic acid residues, and seemed to be involved in the learning and memory. However, the molecular mechanisms and functions of GQ1b is not well understood. Studies were initiated to determine the effect of GQ1b on the improvement of the learning and memory of rats by using the Y-maze and Morris water maze test. The spatial learning and memory of rats was improved by GQ1b treatment into the rat brain. The improvements in spatial memory as measured by these two maze tests are dependent on the hippocampal learning and memory function and related to the N-methyl-D-aspartate (NMDA) receptor signaling pathway. Thus, we showed the activation of NMDA receptor signaling pathway by GQ1b treatment in rat hippocampal cells and rat hippocampus. The activation of NMDA receptor signaling pathway can leads to an enhancement of Brain-derived neurotropic factor(BDNF) mRNA levels and stimulates released of the BDNF protein. BDNF is known to support the survival, growth and differentiation of neurons and mainly expressed in synapses of the hippocampus, cortex, and basal forebrain. We investigated that the expression and the secretion of BDNF were increased by GQ1b treatment in SH-SY5Y cells and rat primary neurons. In addition, GQ1b treatment prevented the effect of D-PDMP, ganglioside synthesis inhibitor, on decrease of BDNF expression in SH-SY5Y cells. To investigate whether NMDA receptor signaling pathways was involved in GQ1b-induced BDNF expression, rat primary neurons were treated with GQ1b and NMDA receptor antagonist D-AP5. Pretreatment with the D-AP5 significantly abolished BDNF expression following GQ1b treatment in primary cortical neurons. These data suggested that GQ1b mediates its effect on BDNF expression through the NMDA receptor activation in the brain. Therefore, ganglioside GQ1b might improve spatial learning and memory and regulate the expression and the secretion of BDNF via activation of NMDA receptors signaling pathway.
저자
간행물 정보
발행기관
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- 발행기관명
- 한국당과학회 [Korean Society for Glycoscience]
- 설립연도
- 2006
- 분야
- 의약학>약학
- 소개
- 본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.
간행물
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- 간행물명
- 한국당과학회 학술대회
- 간기
- 연간
- 수록기간
- 2006~2022
- 십진분류
- KDC 517 DDC 614
이 권호 내 다른 논문 / 한국당과학회 학술대회 2011 한국당과학회 동계 학술대회
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