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SYM-5, Session II: Chitin & Chitosan, Chair: Kisung Ko (Wonkwang University)
Biological Activities of Chitooligosaccharides and Their Derivatives
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- 발행기관
- 한국당과학회 바로가기
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- 간행물
- 한국당과학회 학술대회 바로가기
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- 통권
- 2011 한국당과학회 동계 학술대회 (2011.01)바로가기
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- 페이지
- pp.9-10
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A192610
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- Recently, a great deal of interest has been developed to isolate novel bioactive compounds from natural resources due to their numerous health beneficial effects. Among them, the polysaccharides are widely distributed in the nature and their molecular structures have caused to their various biological activities. Chitosan is a naturally abundant β-1,4-linked copolymer of N-acetyl-2-amino-2-deoxy-D-glucopyranose and 2-amino-2-deoxy-Dglucopyranose units and is a naturally occuring, biodegradable, non-allergenic deacetylated derivative of chitin, found abundantly in nature. Even though chitosan is known to have important functional activities, poor solubility makes them difficult to use in the food and biomedicinal applications. Unlike chitosan, its hydrolyzed products as chitosan oligosaccharides (COS) are readily soluble in water due to their shorter chain lengths and free amino groups in D-glucosamine units. The bioactive properties of chitosan and COS depend on their degrees of deacetylation and molecular weight. Until now, there are very less information available on bioactive properties based on both degrees of deacetylation and their molecular size. It has been reported that novel COS derivatives can be used as physiologically bioactive materials since they possess various health beneficial biological activities, such as antioxidative, antitumor, antimicrobial, anti-hypertensive, antidiabetic, calcium absorption enhancing hypo-cholesterolemic activities and immune enhancing effects. Therefore, it is needful to prepare various types of COS derivatives, such as N-acetyl COS, Amino ethyl-COS (AE-COS), Demethyl amino ethyl-COS (DMAE-COs) and sulfated COS with different degrees of deacetylation and molecular weight. furthermore, the determination of their uninvestigated biological activities such as enzyme inhibitory (β-secretase, MMP, AchE), intra-cellular free radical scavenging, and anti-HIV activities are useful to expand the health of human being. The use of these novel COS derivatives as nutraceuticals, functional foods, pharmaceuticals and cosmeceutical promissing.
저자
간행물 정보
발행기관
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- 발행기관명
- 한국당과학회 [Korean Society for Glycoscience]
- 설립연도
- 2006
- 분야
- 의약학>약학
- 소개
- 본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.
간행물
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- 간행물명
- 한국당과학회 학술대회
- 간기
- 연간
- 수록기간
- 2006~2022
- 십진분류
- KDC 517 DDC 614
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