Sujin Park, Si-Hyoung Park, Ju Yuel Baek, Kwan Soo Kim, Jürgen Roth, Jin Won Cho, Kwang-Min Choe
언어
영어(ENG)
URL
https://www.earticle.net/Article/A192594
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원문정보
초록
영어
Modification of nuclear and cytosolic proteins by O-linked N-acetylglucosamine (O-GlcNAc) is ubiquitous in cells. The in vivo function of the protein O-GlcNAcylation, however, is not well understood. Here, we genetically manipulated the cellular O-GlcNAcylation level in Drosophila and found that it promotes developmental growth by enhancing insulin signaling. This alteration of growth is due to cell growth and apoptosis and not to cell proliferation, and is mediated, at least in part, through O-GlcNAcylation of Akt. These results indicate that O-GlcNAcylation is one of the crucial mechanisms involved in control of insulin signaling in normal Drosophila development.
저자
Sujin Park [ World Class University Program, Department of Biomedical Science, Yonsei University ]
Si-Hyoung Park [ Department of Biology, Yonsei University ]
Ju Yuel Baek [ Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University ]
Kwan Soo Kim [ Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University ]
Jürgen Roth [ World Class University Program, Department of Biomedical Science, Yonsei University ]
Jin Won Cho [ World Class University Program, Department of Biomedical Science, Yonsei University, Department of Biology, Yonsei University ]
Kwang-Min Choe [ Department of Biology, Yonsei University ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.