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O-GlcNAc Protein Modification in Cancer Cells Increases in Response to Glucose Deprivation through Glycogen Degradation

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2010년 한국당과학회 하계학술대회 (2010.06)바로가기
  • 페이지
    pp.93-94
  • 저자
    Jeong Gu Kang, Sang Yoon Park, Suena Ji, Insook Jang, Sujin Park, Hyun Sil Kim, Sung-Min Kim, Jong In Yook, Yong-Il Park, Jürgen Roth, Jin Won Cho
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A192592

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원문정보

초록

영어
When cellular glucose concentrations fall below normal levels, in general the extent of protein O-GlcNAc modification (O-GlcNAcylation) decreases. However, recent reports demonstrated increased O-GlcNAcylation by glucose deprivation in HepG2 and Neuro-2a cells. Here, we report increased O-GlcNAcylation in non-small cell lung carcinoma A549 cells and various other cells in response to glucose deprivation. Although the level of O-GlcNAc transferase was unchanged, the enzyme contained less O-GlcNAc, and its activity was increased. Moreover, O-GlcNAcase activity was reduced. The studied cells contain glycogen, and we show that its degradation in response to glucose deprivation provides a source for UDP-GlcNAc required for increased O-GlcNAcylation under this condition. This required active glycogen phosphorylase and resulted in increased glutamine:fructose-6-phosphate amidotransferase, the first and rate-limiting enzyme in the hexosamine biosynthetic pathway. Interestingly, glucose deprivation reduced the amount of phosphofructokinase 1, a regulatory glycolytic enzyme, and blocked ATP synthesis. These findings suggest that glycogen is the source for increased O-GlcNAcylation but not for generating ATP in response to glucose deprivation and that this may be useful for cancer cells to survive.

저자

  • Jeong Gu Kang [ From the Department of Biology The Catholic University of Korea, Bucheon 420-743, Korea ]
  • Sang Yoon Park [ From the Department of Biology The Catholic University of Korea, Bucheon 420-743, Korea ]
  • Suena Ji [ From the Department of Biology The Catholic University of Korea, Bucheon 420-743, Korea ]
  • Insook Jang [ From the Department of Biology The Catholic University of Korea, Bucheon 420-743, Korea ]
  • Sujin Park [ From the Department of Biology The Catholic University of Korea, Bucheon 420-743, Korea ]
  • Hyun Sil Kim [ Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry ]
  • Sung-Min Kim [ Yonsei University, The Department of Biotechnology and Biomaterial Engineering Research Center ]
  • Jong In Yook [ Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry ]
  • Yong-Il Park [ Yonsei University, The Department of Biotechnology and Biomaterial Engineering Research Center ]
  • Jürgen Roth [ WCU program, Department of BiomedicalScience ]
  • Jin Won Cho [ From the Department of Biology, WCU program, Department of BiomedicalScience ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

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