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Cell Death and Differential Expression Patterns of Gangliosides in Micro-pig Aortic Endothelial Cells treat with Human Serum

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2010년 한국당과학회 하계학술대회 (2010.06)바로가기
  • 페이지
    pp.67-68
  • 저자
    Jin-Hyoung Cho, Dong-Hoon Kwak, Kyu-Tae Chang, Ji-Su Kim, Jae-Sung Ryu, So-Dam Lee, So-Hyun Lee, Ju-Taek Lee, Da-Hyun Park, Seul-Yi Lee, Young-Choon Lee, Young-kug Choo
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A192578

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원문정보

초록

영어
Ganglioside are ubiquitous membrane component in mammalian cells and suggested to play important roles in various cell functions such as cell-cell recognition, differentiation and transmembrane signaling. These compounds are localized in a glycosphingolipid-enriched microdomain on the cell surface and regulated by the glycosphingolipid composition. However, the role that gangliosides play in immune rejection response by xenotransplantation is not yet clearly understood. In this study, differential expression patterens of gangliosides between human vein endothelial cells (ECV304) and micro-pig aortic endothelial cells (MPAECs, primary cultured) was investigated. we examined expression level of high-performance thin-layer chromatography (HPTLC) showed that ECV304 cells contained GM3 and GM2 as major gangliosides. However, MPAECs contained only GM3 as major ganglioside. Furthermore, we confirmed that human serum induces cell death of MPAECs. As a results suggest that differential expression patterens of gangliosides of ECV304, MPAECs are related immune rejection response and cell death with xenogeneic serum in xenotransplantation by biomarker. This study was supported by a grant from the Korean Rural Development Administration Agenda Program, 2010030106112200103) and a research grant from the Ministry of Education, Science and Technology (KGC5401011), Republic of Korea.

저자

  • Jin-Hyoung Cho [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
  • Dong-Hoon Kwak [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
  • Kyu-Tae Chang [ National Primate Research Center (NPRC), Korea Research Institute of Bioscience & Biotechnology, Ochang, Chungbuk ]
  • Ji-Su Kim [ National Primate Research Center (NPRC), Korea Research Institute of Bioscience & Biotechnology, Ochang, Chungbuk ]
  • Jae-Sung Ryu [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
  • So-Dam Lee [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
  • So-Hyun Lee [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
  • Ju-Taek Lee [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
  • Da-Hyun Park [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
  • Seul-Yi Lee [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
  • Young-Choon Lee [ Department of Biotechnology and Biological Science, Dong-A University, Pusan ]
  • Young-kug Choo [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

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