Ju-Taek Lee, Jae-Sung Ryu, Dong Hoon Kwak, Jin-Hyoung Cho, So-Dam Lee, Da-Hyun Park, Seul-Yi Lee, Yun Jum Park, Seong Sun Kang, Pyoung Jun Kim, Young-kug Choo
언어
영어(ENG)
URL
https://www.earticle.net/Article/A192577
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원문정보
초록
영어
Gangliosides are complex glycosphingolipids that contain one or more sialic acids, the major components of cytoplasmic cell membranes. these are tought to play a role in the control of biological processes including cell surface interaction, cell differentiation and transmembrane signaling. Particularly, ganglioside GM3 is abundant in the kidney tissue. Diabetes mellitus is one of the most serious metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both, associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessel. In this study, we demonstrated that gangliosides expression patterns on kidney of mulberry-treated to STZ-induced diabetic rats. High-performance thin-layer chromatography analysis and immunostating showed that ganglioside GM3, GM2, GM1, GD1a, GD1b and GT1b were expressed in normal rats kidney, whereas ganglioside expression were strongly reduced in the kidney of diabetic rats. In 1.0% mulberry administration to diabetic rats kidney, ganglioside GM3, GM2 and GM1 expression were not different compared to normal rats kidney, whereas the other bands were not seen. Therefore, alteration of ganglioside expression in kidney of STZ-induced diabetic rats seem to be importantly involved in the development of glomerular hypertrophy and proteinuria.
저자
Ju-Taek Lee [ Department of Biological Science, Wonkwang University, Iksan, Jeonbuk ]
Jae-Sung Ryu [ Department of Biological Science, Wonkwang University, Iksan, Jeonbuk ]
Dong Hoon Kwak [ Department of Biological Science, Wonkwang University, Iksan, Jeonbuk ]
Jin-Hyoung Cho [ Department of Biological Science, Wonkwang University, Iksan, Jeonbuk ]
So-Dam Lee [ Department of Biological Science, Wonkwang University, Iksan, Jeonbuk ]
Da-Hyun Park [ Department of Biological Science, Wonkwang University, Iksan, Jeonbuk ]
Seul-Yi Lee [ Department of Biological Science, Wonkwang University, Iksan, Jeonbuk ]
Yun Jum Park [ Division of Horticulture and Pet Animal-Plant Science, Wonkwang University, Iksan ]
Seong Sun Kang [ Rural Developement Administration, Buan, Jeonbuk ]
Pyoung Jun Kim [ Rural Developement Administration, Buan, Jeonbuk ]
Young-kug Choo [ Department of Biological Science, Wonkwang University, Iksan, Jeonbuk ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.