Ganglioside are ubiquitous membrane component in mammalian cells and suggested to play important roles in various cell functions such as cell-cell recognition, differentiation and transmembrane signaling. These compounds are localized in a glycosphingolipid-enriched microdomain on the cell surface and regulated by the glycosphingolipid composition. However, the role that gangliosides play in immune rejection response by xenotransplantation is not yet clearly understood. In this study, differential expression patterens of gangliosides of Micro-Pig solid organs, which are heart, kidney, liver, pancreas and spleen. We examined expression level of high-performance thin-layer chromatography (HPTLC) showed that all of solid organs contained GM3, GM2, GM1 and GD1a as major gangliosides. Especially, ganglioside GD1b expressed in liver and pancreas, not in heart, kidney and spleen. Also, GT1b expressed in liver, kidney and spleen, not in heart and pancreas. As a results suggest that differential expression patterens of gangliosides of Micro-Pig solid organs are related immune rejection response in xenotransplantation by biomarker.
저자
So-Dam Lee [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
Dong-Hoon Kwak [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
Kyu-Tae Chang [ National Primate Research Center (NPRC), Korea Research Institute of Bioscience & Biotechnology, Ochang, Chungbuk ]
Ji-Su Kim [ National Primate Research Center (NPRC), Korea Research Institute of Bioscience & Biotechnology, Ochang, Chungbuk ]
Jae-Sung Ryu [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
Jin-Hyoung Cho [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
So-Hyun Lee [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
Ju-Taek Lee [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
Da-hyun Park [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
Seul-Yi Lee [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
Young-Choon Lee [ Department of Biotechnology and Biological Science, Dong-A University, Pusan ]
Young-kug Choo [ Department of Biological Science, College of Natural Sciences, WonkwangUniversity, Iksan ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.