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Production of glucocerebrosidase with high-mannose type N-glycan in plants

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    4th 2009 Annual Meeting of Korean Society for Glycoscience in 2009 (2009.11)바로가기
  • 페이지
    pp.52-52
  • 저자
    In Jung Jung, Jeong Chan Moon, Joo Mi Jeon, Wahyu Indra Fanata, Bo Hwa Son, Jae Yong Yoo, Jae Ho Cha, Je Hein Kim, Rikno Harmoko, Ki Seong Ko, Sang Yeol Lee, Kyun Oh Lee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A192538

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원문정보

초록

영어
Plant-based expression of recombinant proteins offers significant advantages in terms of the production of pharmaceuticals for human diseases. These include cost-effective production of recombinant proteins due to the ease of scale-up, minimal possibility of product contamination by animal pathogens and the availability of natural storage organs such as tubers, fruits and seeds. Among the many plant-based production systems that have been developed for pharmaceuticals proteins, seeds have the useful advantage of accumulating proteins in a relatively small volume and in stable environment in which they are protected from degradation. In this respect, we overexpressed human glucocerebrosidase (GC) in Arabidopsis seeds driven by cruciferin 3 promoter. In attempt to produce mannose-terminated N-glycan of GC, the construct was introduced into Arabidopsis gnt1 mutant deficient in the activity of N-acetylglucosaminyltransferase I, the first enzyme in the complex glycan biosynthesis. Our results indicate that the human GC is highly expressed in the seed. [Supported by EB-NCRC & BK21 program]

저자

  • In Jung Jung [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]
  • Jeong Chan Moon [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]
  • Joo Mi Jeon [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]
  • Wahyu Indra Fanata [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]
  • Bo Hwa Son [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]
  • Jae Yong Yoo [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]
  • Jae Ho Cha [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]
  • Je Hein Kim [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]
  • Rikno Harmoko [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]
  • Ki Seong Ko [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]
  • Sang Yeol Lee [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]
  • Kyun Oh Lee [ Division of Applied Life Science (BK21 Program), EB-NCRC and PMBBRC, Gyeongsang National University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

이 권호 내 다른 논문 / 한국당과학회 학술대회 4th 2009 Annual Meeting of Korean Society for Glycoscience in 2009

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