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O-GlcNAc Modification on E-cadherin repressor Snail confers Epithelial-Mesenchymal Transition

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2009 한국 당과학회 하계 학술대회 (2009.06)바로가기
  • 페이지
    pp.73-74
  • 저자
    Sang Yoon Park, Hyun Sil Kim, Nam Hee Kim, Won Ho Yang, Jeong Gu Kang, Suena Ji, Shi Eun Kang, Ichiro Ota, Keiji Shimada, Noboru Konishi, Mi Heon Ryu, Hyung Wook Nam, Jong In Yook, Jin Won Cho
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A192491

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원문정보

초록

영어
The transcriptional repressor Snail plays a key role in epithelial-mesenchymal transition (EMT) by which direct repression of E-cadherin transcription. Therefore, regulation of Snail expression level in epithelial tumor cells is important not only for maintaining of epithelial homeostasis, but also for invasion and metastasis of cancer cells by the EMT program. Series of Ser imbedded in Snail are phosphorylated by GSK3 and Snail expression is dynamically regulated by Wnt signaling together with β-catenin while driving a Snail-dependent EMT program. Glucose flux through the hexosamine biosynthetic pathway (HBP) can be used for the source of O-linked β-N-acetylglucosamine(O-GlcNAc) modification on Ser and Thr residues of various nucleocytoplasmic proteins. In this study, we demonstrate that Ser112 of Snail is O-GlcNAcylated and this adjacent-site occupancy inhibits phosphorylation by GSK-3, resulting in increased Snail stability and attenuation of E-cadherin proximal promoter activity and transcription level. Furthermore, Overexpression of OGT induces in vivo invasion program of epithelial cancer cells by Snail-dependent manner. Taken together, our results indicate dynamic interplay between O-GlcNAcylation and GSK-3 phosphorylation of Snail, and our observations may provide the molecular insight of pathogenic and prognostic correlation between cancer progression and hyperglycemic condition of diabetes.

저자

  • Sang Yoon Park [ Department of Biology, Yonsei University, These authors contributed equally to this work ]
  • Hyun Sil Kim [ Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry Yonsei University, These authors contributed equally to this work ]
  • Nam Hee Kim [ Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry Yonsei University ]
  • Won Ho Yang [ Department of Biology, Yonsei University ]
  • Jeong Gu Kang [ Department of Biology, Yonsei University ]
  • Suena Ji [ Department of Biology, Yonsei University ]
  • Shi Eun Kang [ Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry Yonsei University ]
  • Ichiro Ota [ Departments of Otolaryngology ]
  • Keiji Shimada [ Pathology, Nara Medical University School of Medicine, 840Shijo-cho,Kashihara,Nara634-8522Japan ]
  • Noboru Konishi [ Pathology, Nara Medical University School of Medicine, 840Shijo-cho,Kashihara,Nara634-8522 Japan ]
  • Mi Heon Ryu [ Department of Oral Pathology, College of Dentistry, Pusan National University, Pusan, Korea ]
  • Hyung Wook Nam [ Department of Biochemistry, Yonsei University ]
  • Jong In Yook [ Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry Yonsei University ]
  • Jin Won Cho [ Department of Biology, Yonsei University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

이 권호 내 다른 논문 / 한국당과학회 학술대회 2009 한국 당과학회 하계 학술대회

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