We isolated human mesenchymal stem cells (hMSC) from dental pulp. These cells are multipotent and serve as precursors for various mesoderm-type cells such as osteoblasts, chondroblasts and adipocytes, as well as several other types of cells. This study investigated the possible role of gangliosides in osteoblast differentiation of hMSCs. Gangliosides, which exist in glycosphingolipid-enriched domains on the cell membrane The role of gangliosides that play in osteoblastogenesis is not yet clearly understood. Therefore, in this study, We investigated the relationship between gangliosides and osteoblast differentiation of human mesenchymal stem cells (hMSCs). The results of high-performance thin-layer chromatography (HPTLC) showed that ganglioside GD1a expression was increased during the differentiation of hMSCs into osteoblasts. Furthermore, we showed that involvement of alkaline phosphate (ALP) with GD1a by immunostaining. Taken together, these results suggest that gangliosides GD1a may play a role in the osteoblast differentiation process of hMSCs.
저자
Hyo-Jung Yang [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk ]
Jae-Sung Ryu [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk ]
Jung-Woo Jin [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk ]
Jin-Hyoung Cho [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk ]
Eun-Jeong Jeong [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk ]
So-Dam Lee [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk ]
So-Hyun Lee [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk ]
Young-Kug Choo [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.