Earticle

초록

영어

A great deal of effort has been devoted to the elucidation of the cell wall structure of Mycobacteriumtuberculosis, the causal agent of human tuberculosis, in recent years owing to the appearance of its multi-drug resistant strains. One of the major structural components of the cell wall of is the complex of mycolic acid, arabinogalactan (AB), and peptidoglycan, which plays a extremely important role for the survival and pathogenicity of M. tuberculosis. Novel cyclicgalactooligosaccharides 1, 2, and 3 were identified amongst the degradation products of AG by extracellular enzymes isolated from Cellulomonas sp. Herein we report the synthesis of cyclic tetra-, hexa- and octasaccharides 1, 2, and 3 including the alternating (1→5)-β-, and (1→6)-β- galactofuranosyl linkages by the intramolecular cycloglycosylation of corresponding linear sugars and by the cylclooligomerization of 1,5-linked and 1,6-linked disaccharides, 4 and 5. Notably, the cyclooligomerization of (1→6)-β-galactofuranosyl disaccharide 5 presented an effective way to secure all three cyclic sugars in one operation.

저자

• Bo-Young Lee [ Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University ]
• Seul Gi Lee [ Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University ]
• Kwan Soo Kim [ Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국당과학회 학술대회

• 간기

  연간

• 수록기간

  2006~2022

• 십진분류

  KDC 517 DDC 614