2008 Eastern Asian Glycoscience Symposium (2008.11)바로가기
페이지
pp.36-36
저자
Jung Sun Yum
언어
영어(ENG)
URL
https://www.earticle.net/Article/A192306
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원문정보
초록
영어
The hepatitis B virus (HBV) is the major cause of liver disease worldwide. The World Health Organization estimates that 2 billion people (one-third of the world's population) have been infected by HBV. Of these, approximately 400 million people have chronic infections that put them at high risk of ultimately developing cirrhosis and cancer of the liver and the death of liver tissue. In China alone, more than 100 million people have chronic HBV infections. The currently available HBV vaccine needs some improvement to induce protection among the nonresponders and also to apply the immune therapy for the chronic carriers. To improve immunogenicity of the HBV vaccine antigen, we have successfully developed a CHO cell line that can express all three types of envelope proteins (L protein, M protein and S protein) in the form of virus-like particles which are observed in the blood of HBV chronic patients. The preS antigens are exposed at the external surface of the particles composed of S antigens and the virus-like particles are properly glycosylated. Using this antigen, we have developed a strong HBV vaccine which can break immune tolerance and induce strong immune responses in a transgenic mouse model.
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.
간행물
간행물명
한국당과학회 학술대회
간기
연간
수록기간
2006~2022
십진분류
KDC 517DDC 614
이 권호 내 다른 논문 / 한국당과학회 학술대회 2008 Eastern Asian Glycoscience Symposium