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Session III : Microbial Glycosciences - Bioactive Carbohydrates & Enzymes, Chair : Dr. Yong Il Park (Catholic Univ. of Korea, Korea)
How Does Host Recognize Bacterial Peptidoglycan and Fungal beta-1,3-Glucan during Innate Immune Reactions?
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- 발행기관
- 한국당과학회 바로가기
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- 간행물
- 한국당과학회 학술대회 바로가기
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- 통권
- 2008 Eastern Asian Glycoscience Symposium (2008.11)바로가기
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- 페이지
- pp.22-23
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A192298
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- Peptidoglycan (PG) recognition protein (PGRP)-SA and Gram-negative bacteria binding proteins (GNBPs) are suggested to function as lectin-like molecules during Drosophila Toll signaling pathway. However, the molecular mechanisms of how bacterial PG and fungal beta-1,3-glucan recognition signals triggered by PGRP-SA and GNBP molecules are transferred to downstream factors are not clearly determined yet. The elegant Drosophila genetic studies have been and are very powerful for characterizing and arranging the components of the Drosophila Toll pathway. There is a limit with only genetic studies since the mechanisms involved in regulating and controlling this proteolytic cascade have done using a biochemical approach. To identify all essential components necessary for the transferring PGRP-SA or GNBP-mediated recognition signaling pathway, the biochemical approach was performed using the hemolymph of a large beetle, Tenebrio molitor larvae. For the activation of lysine (Lys)-type PG recognition signaling pathway, Lys-type PG/PGRP-SA/GNBP1/modular serine protease (MSP)/ Spätzle processing enzyme activating enzyme (SAE)/Spätzle processing enzyme (SPE)/Spätzle (Spz) cascade is an essential unit that triggers the Lys-type PG recognition signaling pathway in response to Gram-positive bacteria infection. For triggering fungal beta-1,3-glucan recognition signal, beta-1,3-glucan/GNBP3/MSP/SAE/SPE/Spz cascade is enough for transferring beta-1,3-glucan recognition signal in response to fungal infection.. The activation mechanisms of how the PGRP-SA-mediated Lys-type PG recognition signal and of how GNBP3-mediated beta-1,3-glucan recognition signal are transferred to Spz, leading to antimicrobial activity in vivo, is provided. Finally, we purified and determined the whole sequences of the induced antimicrobial peptides after injection of Lys-PG, beta-1,3-glucan, SAE and Spz to the Tenebrio larvae. Our data provides the first biochemical evidences of how the PGRP-SA-mediated Lys -type PG recognition signal and GNBP3-mediated beta-1,3-glucan recognition signal are transferred to Spätzle via PGRP-SA and GNBPs, leading to antimicrobial activities in vivo.
저자
간행물 정보
발행기관
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- 발행기관명
- 한국당과학회 [Korean Society for Glycoscience]
- 설립연도
- 2006
- 분야
- 의약학>약학
- 소개
- 본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.
간행물
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- 간행물명
- 한국당과학회 학술대회
- 간기
- 연간
- 수록기간
- 2006~2022
- 십진분류
- KDC 517 DDC 614
이 권호 내 다른 논문 / 한국당과학회 학술대회 2008 Eastern Asian Glycoscience Symposium
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