Earticle

초록

영어

There are conflicting reports regarding circadian variation in the onset of acute myocardial infarction (MI) among patients with diabetes. We therefore, studied the circadian pattern of the incidence of acute MI in patients (n = 3,882) who were enrolled in the Onset Study stratified by the presence, type, and duration of diabetes. The Onset Study was conducted at 64 U.S. medical centers between August 1989 and September 1996. We used harmonic regression model to evaluate the circadian variation of MI symptom onset in patients with and without diabetes. Subgroup analysis was performed according to the presence, type, and duration of diabetes by the 2 test (dividing the day into four 6-h intervals). Patients without diabetes exhibited a prominent morning peak in the incidence of acute MI symptom onset (P< 0.001). In contrast, patients with type 1 diabetes and type 2 diabetes ≥ 5 years had a marked attenuation of the morning peak. Patients who had type 2 diabetes diagnosed within the previous 5 years had a pattern of onset of acute MI similar to patients without diabetes. Patients with type 1 diabetes and those with type 2 diabetes ≥5 years have an attenuation of the morning peak in acute MI. Inconsistency in observation of such an effect in patients with diabetes in the past may well have been due to difference in the duration of diabetes and thus the variable extent of underlying autonomic dysfunction.

목차

ABSTRACT
 I. 서론
 II. 연구 계획 및 방법
 III. 결과
 IV. 고찰
 참고문헌

키워드

저자

• 이나래 [ Lee Na-Rae | 인제대학교 뇌과학협동과정 ]
• 홍용근 [ Hong Yong-Geun | 인제대학교 뇌과학협동과정, 의생명공학대학 물리치료학과, 심혈관 및 대사성질환 센터 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  대한건강과학학회지 [Journal of Korean society of health sciences]

• 간기

  반년간

• pISSN

  1738-401X

• 수록기간

  2004~2025

• 십진분류

  KDC 517 DDC 613