Hyun-Myoung CHA, Joon-Serk SEO, Min-Ho CHOI, Ji-Sung PARK, Dong-Il KIM
언어
영어(ENG)
URL
https://www.earticle.net/Article/A187510
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Mesenchymal stem cells (MSCs) are important tools for cell therapy. They have capabilities of self-renewal and differentiation into various types of cells for therapeutic purposes. MSCs are commonly cultured in two-dimensional (2D) system. However, MSCs can lose their differentiation capacity with time in 2D culture. In addition, available surface area for the propagation of cells is limited. Therefore, various three-dimensional (3D) culture systems have been suggested. In this study, we have developed a 3D culture system for the expansion of periosteum-derived progenitor cells (PDPCs) as spheres. The PDPCs are one of diverse MSCs and they have high proliferation capacity. The spheroid formation of PDPCs was induced by using a rotation platform. The spheres maintained both their viability and proliferation ability. Furthermore, the properties of stem cells have been improved in 3D cultures. In conclusion, a simple and economical 3D culture system could be developed. The 3D culture system can increase the potential of PDPCs for clinical use.
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동