1.063 g/mL and 0.901 g./mL of saponins were obtained from 50 g (dry weight) of tea seed with/without sonication, respectively, with newextraction methods for greentea seed saponin. Sonicated samples was enhanced by 15.23% than the untreated sample. The results of cytotoxicity of tea seed saponin by MTT assay with different concentration, so, it could be used for various purposes. The inhibitory effect of greentea seed saponin on breast cancer cells, cervical cancer, liver cancer and stomach cancer cells was observed more than 80% inhibition at 5 ppm, especially, stomach cancer cells showed completely supressed. Five kinds of strains by using antimicrobial test results, 5 kinds of strains that were significantly inhibited at 50 ppm of tea seed saponin extract. While ob mouse treated with a high fat diet and treated with tea seed saponin, and weight loss was investigated. As a result, compared to the control group appeared to be reduced by more than 30% weight, so it show that tea seed saponin is to be a good substance for anti-obesity. From the above results, Tea-saponin E1 from green tea seed extract was showed novel angiogenesis inhibitory effect and antitumor activity.
키워드
Anti-angiogenesisGreentea seedAnti-obesity
저자
Jong Deog KIM [ Department of Biotechnology, Research center on Anti-Obesity and Health Care, Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea. ]
Hyo Jin SEO [ Dept. of Biotechnology, Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea. ]
Tai Sun SHIN [ 2Dept. of Food Science and Nutrition, Chonnam Natational University, San96-1, Dun-Duk Dong, Yeosu, Chonnam, 550-749, Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동