Earticle

초록

영어

The oocyte and its surrounding granulosa cells co-exist in a closed compartment called a follicle, although they receive many signals from other parts of the body. It is well established that the intercellular communications between the oocyte and granulosa cells are required for normal oocyte development and ovulation during folliculogenesis. Gap junctions are intercellular channels allowing the direct transmission of ions and small molecules between coupled cells. Several lines of studies have shown that multiple connexins (Cx, subunits of gap junction) are expressed in mammalian ovarian follicles. Among them, two major connexins Cx37 and Cx43 are expressed in different manner. While the gap junction channels formed by Cx37 are localized between the oocyte and encompassing granulosa cells, the intercellular channels by Cx43 are located between granulosa cells. In this review, I will summarize the general properties of gap junction channels and discuss their possible formation (or compatibility) of intercellular channels formed by the oocyte and granulosa cells.

목차

INTRODUCTION
 STRUCTURE OF GAP JUNCTION
 CONNEXIN GENE FAMILY
 MODULATION OF GAP JUNCTION
  Physphorylation of Cx43
 IONIC SELECTIVITY AND MOLECULAR PERMEABILITY
  Cx37 Gap Junction Channels
  Cx43 Gap Junction Channels
 INTERCELLULAR CHANNEL FORMATION
  Heterotypic Channels
  Heteromeric Channels
  Heteromeric Channels between Cx37 and Cx43 in Exogenous System
  'Chimeric' Channels Formation in Ovarian Follicles
 CONCLUSIONS
 REFERENCES

키워드

저자

• Oh Seunghoon [ Department of Physiology, College of Medicine, Dankook University ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Reproductive & developmental biology

• 간기

  계간

• pISSN

  1738-2432

• eISSN

  2288-0151

• 수록기간

  1977~2018

• 십진분류

  KDC 527 DDC 636