Earticle

초록

영어

The stability of triamcinolone in three kinds of oral liquid syrups at 4 and 25oC was studied for 21 days. Twenty tablets of 4 mg triamcinolone were mixed with 100 mL of each oral liquid syrup, which is Levotuss®Syrup (levodropropizine 6 mg/mL), Ucerax®Syrup (hydroxyzine 2 mg/mL), and Xyzal®Liquid (levocetirizine 0.5 mg/mL). The chromatographic analysis after deliberate degradation showed no evidence of any breakdown product likely to interfere with the chromatographic peak of the parent substance. The relationship between triamcinolone concentrations and peak areas was linear from 50 to 1000 μg/ mL (r2 = 0.9998). The analysis method was precise, with coefficients of variation no greater than 5.4%. Triamcinolone was stable for up to 14 and 21 days in Levotuss®Syrup at 25 and 4oC, respectively; in Ucerax®Syrup and Xyzal ®Syrup, it was stable for at least 21 days at both temperatures. The percentages of initial triamcinolone concentration remaining after 21 days were 72.3±3.2 and 94.9±6.0% and 93.2±4.9 and 92.4±5.7%, and 92.6±1.2 and 92.7±2.2% in Levotuss®Syrup, Ucerax®Syrup, and Xyzal®Syrup at 25 and 4oC, respectively. The pH variations of all test solutions were within 0.8. Based on the results, it was concluded that triamcinolone in three oral liquid syrups which are Levotuss®syrup, Ucerax®syrup and Xyzal®syrup was chemically and physically stable in both states of refrigeration and room temperature for at least 14 days.

목차

Abstract
 연구방법
  시약 및 재료
  High Performance Liquid Chromatography 분석법
  검량선 작성 및 분석법 밸리데이션
  가혹시험
  안정성 시험
  결과처리
 연구 결과
 고찰 및 결론
 참고문헌

키워드

저자

• 윤희영 [ Hee Young Yoon | 이화여자대학교 임상보건과학대학원 ]
• 이병구 [ Byung Koo Lee | 이화여자대학교 임상보건과학대학원, 이화여자대학교 약학대학/생명약학부 ]
• 곽혜선 [ Hye Sun Gwak | 이화여자대학교 임상보건과학대학원, 이화여자대학교 약학대학/생명약학부 ] Correspondence to

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615