Earticle

초록

영어

Purpose: The purpose of the present study was to investigate the pharmacokinetics of urea, a new potential diagnosis reagent of Helicobacter pylori infection. Methods: Considering the mechanism of urea breath test, we determined the excretion of urea in expired air after its oral administration in rats and beagle dogs at the dose of 2 mg/kg (including 50 mCi/mmol 14C-urea 50 μCi/kg for rats and 13.5 μCi/kg for dogs). Results: Urea was rapidly disappeared from the blood circulation by 1 hr after its i.v. bolus injection, followed by a slow disappearance by 24 hr. The half-lives at the distributive phase (t1/2α) and post-distributive phase (t1/2β) were 2 min and 6 hr, respectively. The bioavailability of urea was 64.3% after its oral administration. The values of the volume of distribution (Vdss) and the total body clearance (CLt) after the oral administration were compatible with those after i.v. administration. The recovery of urea in the bile was about 0.1% of the dose by 24 hr after its oral administration. Urea was extensively eliminated in the urine by 48 hr. The recovery ratios of urea in the urine and expired air were about 86.8% and 2.99% of the dose by 48 hr, respectively. Moreover, urea was mostly distributed from the blood circulation to the kidney, followed by being eliminated in the urine without metabolism. The concentration of urea in the kidney was 4.0 times higher than that of plasma at 40 min after its oral administration. Conclusions: These findings indicated that oral route appears to be available for the administration of urea. Orally administered urea, thus, was considered to be useful for the diagnosis of Helicobacter pylori infection.

목차

Abstract
 실험방법
  실험재료 및 기기
  14C-urea 분석
  정맥투여 후 혈장중 농도 측정
  경구투여 후 혈장중 농도 측정
  경구투여 후 조직분포 실험
  경구투여 후 담즙배설 실험
  경구투여 후 요 중 배설 실험
  경구투여 후 호기 중 배설 실험
  약물동태학적 해석
  모델비의존적 해석
  통계처리
 실험결과 및 고찰
  정맥주사 후 혈장 중 농도 패턴
  경구투여 후 혈장 중 농도 패턴
  경구투여 후 담즙, 요 및 호기 중 배설
  경구투여 후 조직 분포
 결론
 감사의 말씀
 참고문헌

키워드

저자

• 박승혁 [ Seung Hyeok Park | 충북대학교 약학대학 ]
• 신대환 [ Dae Hwan Shin | 충북대학교 약학대학 ]
• 조한준 [ Han Jun Cho | 충북대학교 약학대학 ]
• 임주빈 [ Ju Bin Yim | 충북대학교 약학대학 ]
• 임성실 [ Sung Cil Lim | 충북대학교 약학대학 ]
• 한건 [ Kun Han | 충북대학교 약학대학 ]
• 정연복 [ Youn Bok Chung | 충북대학교 약학대학 ] Correspondence to

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615