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Chitosan Nanoparticles Treatment in In Vitro Culture Medium Induces Apoptosis in the Inner Cell Mass

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Reproductive & Developmental Biology(Supplement) 바로가기
  • 통권
    Volume 36 No 2 Supplement (2012.06)바로가기
  • 페이지
    pp.107-107
  • 저자
    Mi‐Ryung Park, Jin‐Hoi Kim, Min‐Hui Kang, Jae‐Woong Han, Gurunathan Sangiliyandi, Deug‐Nam Kwon
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A178367

원문정보

초록

영어
Although there are a number of reports regarding the toxicity evaluation of inorganic nanoparticles, knowledge on biodegradable nanomaterials, which have always been considered safe, is still limited. For example, the toxicity of chitosan nanoparticles, one of the most widely used drug/gene delivery vehicles, is largely unknown. In this report, we examined the cytotoxic effects of chitosan nanoparticles on mouse embryos at the blastocyst stage and in vivo implantation by embryo transfer. Blastocysts treated with 250 nm chitosan nanoparticles exhibited significantly increased apoptosis and a corresponding decrease in total cell number, which was concentration‐dependent. Moreover, the TUNEL positive signal in the embryos exposed to chitosan nanoparticles showed an increased of the ICM and the implantation success rate was lower than that of their control counterparts. Our results collectively indicate that in vitro exposure to chitosan nanoparticles induces apoptosis and retards implantation development after transfer to host mice. The results collectively show that chitosan nanoparticles have the potential to induce embryo cytotoxicity. Further studies are required to establish effective protection strategies against the cytotoxic effects of these nanoparticles.

키워드

Chitosan nanoparticles Mouse embryos Apoptosis Development Cytotoxicity

저자

  • Mi‐Ryung Park [ Department of Animal Biotechnology, College of Animal Bioscience & Biotechnology /Animal Resources Research Center, Konkuk University ]
  • Jin‐Hoi Kim [ Department of Animal Biotechnology, College of Animal Bioscience & Biotechnology /Animal Resources Research Center, Konkuk University ]
  • Min‐Hui Kang [ Department of Animal Biotechnology, College of Animal Bioscience & Biotechnology /Animal Resources Research Center, Konkuk University ]
  • Jae‐Woong Han [ Department of Animal Biotechnology, College of Animal Bioscience & Biotechnology /Animal Resources Research Center, Konkuk University ]
  • Gurunathan Sangiliyandi [ Department of Animal Biotechnology, College of Animal Bioscience & Biotechnology /Animal Resources Research Center, Konkuk University ]
  • Deug‐Nam Kwon [ Department of Animal Biotechnology, College of Animal Bioscience & Biotechnology /Animal Resources Research Center, Konkuk University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Reproductive & Developmental Biology(Supplement)
  • 간기
    연간
  • 수록기간
    2001~2017
  • 십진분류
    KDC 527 DDC 636

이 권호 내 다른 논문 / Reproductive & Developmental Biology(Supplement) Volume 36 No 2 Supplement

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