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A Disease Model Pig Over-Expressing Mouse PEA15 Showed Symptoms of Diabetes Mellitus

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Reproductive & Developmental Biology(Supplement) 바로가기
  • 통권
    Volume 36 No 2 Supplement (2012.06)바로가기
  • 페이지
    pp.69-69
  • 저자
    Hyun-Mi Kim, Hyun-Min Kim, Hak-Jae Chung, Byong-Chul Yang, Kyung-Woon Kim, Jin-Ki Park, Sung-Ku Hong, Hee-Kyung Chung, Won-Kyong Chang, Hwi-Cheul Lee, Deug-Woo Han
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A178337

원문정보

초록

영어
Phosphoprotein Enriched in Astrocytes (PEA15) is a 15kD-sized intracellular signaling protein, highly expressed in astrocytes and constitutively expressed in peripheral tissues. Recently it was found that PEA15 expression was elevated in patients suffering type 2 diabetes and suggested to be involved in the syndrome of insulin resistance. To investigate the functional role of PEA15 for the control of blood glucose level, we produced a transgenic pig over-expressing mouse PEA15 (mPEA15). As a model animal, pig has many advantages. They have a higher fecundity and a short generation time and are physiologically similar to human. Using the transgenic pig, we carried out a series of experiments to establish a link between PEA15 expression and the insulin resistance. Our results suggested that, compared with control pig, mPEA15 pig has, (1) a higher blood resistin level, (2) a lower cell membrane-embeded GLUT4 level, and (3) a lower glucose clearing ability based on oral glucose tolerance test (OGTT). When our results combined, it can be concluded that mPEA15 over-expressing pig has many symptoms of insulin resistance and these pigs will become a useful disease model to investigate diabetes mellitus in the near future.

키워드

Disease model Diabetes Pea15 Transgenic pig Insulin resistance

저자

  • Hyun-Mi Kim [ National Institute of Animal Science, RDA, Suwon, Korea (ROK) ]
  • Hyun-Min Kim [ National Institute of Animal Science, RDA, Suwon, Korea (ROK) ]
  • Hak-Jae Chung [ National Institute of Animal Science, RDA, Suwon, Korea (ROK) ]
  • Byong-Chul Yang [ National Institute of Animal Science, RDA, Suwon, Korea (ROK) ]
  • Kyung-Woon Kim [ National Institute of Animal Science, RDA, Suwon, Korea (ROK) ]
  • Jin-Ki Park [ National Institute of Animal Science, RDA, Suwon, Korea (ROK) ]
  • Sung-Ku Hong [ National Institute of Animal Science, RDA, Suwon, Korea (ROK) ]
  • Hee-Kyung Chung [ National Institute of Animal Science, RDA, Suwon, Korea (ROK) ]
  • Won-Kyong Chang [ National Institute of Animal Science, RDA, Suwon, Korea (ROK) ]
  • Hwi-Cheul Lee [ National Institute of Animal Science, RDA, Suwon, Korea (ROK) ]
  • Deug-Woo Han [ National Institute of Animal Science, RDA, Suwon, Korea (ROK) ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Reproductive & Developmental Biology(Supplement)
  • 간기
    연간
  • 수록기간
    2001~2017
  • 십진분류
    KDC 527 DDC 636

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