Earticle

초록

영어

In this study, an increased surface area crystallization process was evaluated to achieve the effective purification of vancomycin, a glycopeptide antibiotic. In addition, the crystallization behaviors (purity, yield, crystallization time, and particle size) were investigated to establish the optimal crystallization strategies. As surface area-increasing materials, diverse types of ion exchange resin were used to increase the surface area per working volume (S/V). When the S/V was increased, in cation exchange resin Amberlite 200, Amberlite IR 120 (Na), and Amberlite IRC 50 and in anion exchange resin Amberlite IRA 400 (Cl) and Amberlite IRA 910 (Cl), vancomycin crystals were successfully generated. The yield of vancomycin increased (> 97%), and the time necessary for crystallization was reduced dramatically (reduced from 24 hr to 12 hr). On the contrary, increase in the S/V hardly affected the purity of vancomycin (> 95%). In addition, when crystallizing after adding ion exchange resin, a surface area-increasing material, it was possible to obtain even smaller vancomycin crystals than when the resin had not been added.

키워드

저자

• Sung-Jae KIM [ Department of Chemical Engineering, Kongju National University, Cheonan 330-717, Korea. ]
• Eun-A KWAK [ Department of Chemical Engineering, Kongju National University, Cheonan 330-717, Korea. ]
• Jin-Hyun KIM [ Department of Chemical Engineering, Kongju National University, Cheonan 330-717, Korea. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576