Earticle

초록

영어

Corni fructus was screened with anti-angiogenesis experiment for anti-obesity candidate which exerted dose-dependent inhibitory effects against angiogenesis, adipogenesis, and cell adhesion. C. fructus extract (CFE) exhibits an angiogenesis inhibitory effect superior to that of the EGCG from green tea leaves. The expression level of angiogenesis and dipogenesis-related signal molecules in the western blotting was reduced by increasing the amount of added CFE. Also, CFE was suppressed the U937 cell adhesion in a dose-dependent manner, by percentages of 50%, 112%, 231%, and 297%, respectively. The effect of CFE on lipid accumulation was measured with Oil red O staining of 3T3-L1 cell, relative to the control cells, CFE treatment reduced intracellular lipid content in a dose-dependent manner, and the most effective dosage for inhibition was found to be 25 mg/l of CFE, CFE could inhibit lipid accumulation in 3T3-L1 adipocytes in a dose-dependent manner. Moreover, a diet supplemented with CFE was deemed more effective in inducing weight loss in LB mice than a representative synthetic diet drug, orlistat, which incidently caused the side effect of denuding the mice of their hair. These results indicate that C. fructus may prove to be a useful anti-adipogenic compound, and these in vitro results may be reflected later under in vivo conditions.

키워드

저자

• Jong Deog KIM [ Department of Biotechnology,Research center on Anti-Obesity and Health Care, Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea. ]
• Hyo Jin SEO [ Department of Biotechnology, Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea. ]
• Tai Sun SHIN [ Dept. of Food Science and Nutrition, Research center on Anti-Obesity and Health Care, Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550- 749, Korea. ]

참고문헌

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간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576