Earticle

초록

영어

A vital issue for a new drug carrier system based on self-assembly and polymerization of polydiacetylene amphiphiles in clinical application is analyzed. We have developed a novel polymerized vesicular carrier that composes of polydiacetylene and other types of phospholipids. Liposomes loaded with ampicillin as a model hydrophilic drug has been successfully constituted by polymerizable diacetylens into the lipid bilayer vesicle. Furthermore these liposomes were fused rapidly when the medium pH is lowered from 7 to 4. The polymerized liposomes have been characterized in terms of particle size distribution. Liposome fusion was demonstrated by Dynamic light scattering (DLS) and TEM image. Cross-linking of the diacetylene lipids prevents the drug leakage and the encapsulated drug can be instantaneously released at low pH condition. Finally, the therapeutic effect was observed by the appearance of plaques on a lawn of bacteria and fluorescent image of PDA liposomes on plaques. As a result, this research demonstrates that such novel pH-sensitive polymerized liposomes have very good prospect as a drug carrier.

키워드

저자

• Jong Uk LEE [ Dept. of Chemical &Biological engineering, Korea university, Seoul 136-701, Korea. ]
• Sang Jun SIM [ Dept. of Chemical &Biological engineering, Korea university, Seoul 136-701, Korea. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576