Earticle

초록

영어

The continuous spread of microbial pathogens with antibiotic-resistance has led to a growing interest in the design and development of new materials that are effective in killing bacteria. Photodynamic Therapy (PDT) is a promising approach for killing antibiotic- resistant bacterial strains. In this study, we synthesized a novel vancomycin- and photosensitizerconjugated multifunctional particle (MMPs; Fe3O4@t-PtCP&van) and characterized it as a new and effective antimicrobial reagent. The photodynamic killing of seven model organisms, including both gram-positive and gram-negative bacteria, was evaluated. The MMPs was capable of capturing these bacteria from aqueous solution. When captured microorganisms were exposed to the appropriate wavelength (510 nm), the photosensitizer closed to the bacterial surface effectively killed them with a low power density light. Gram-positive bacteria were completely killed in 6 min and gram-negative bacteria in 60 min. Antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) were also effectively killed in 6 min. The MMPs possessing magnetic and photophysical properties can be used in various medical applications, such as in magnetic resonance imaging (MRI) diagnosis, bioseparation, target delivery, and PDT.

키워드

저자

• Hye-Jin LEE [ Dept. of Chemical &Biological Engineering, Korea University, Seoul, 136-701. ]
• Kyong-Hoon CHOI [ Dept. of Chemistry, Yonsei University, Seoul 120-749. ]
• Bong Joo PARK [ Dept. of Medical Engineering, Yonsei University College of Medicine, Seoul 120-752. ]
• Kang-Kyun WANG [ Dept. of Chemistry, Yonsei University, Seoul 120-749. ]
• Eon Pil SHIN [ Dept. of Chemistry, Yonsei University, Seoul 120-749. ]
• Jong-Chul PARK [ Dept. of Medical Engineering, Yonsei University College of Medicine, Seoul 120-752. ]
• Young Keun KIM [ Dept. of Materials Science and Engineering, Korea University, Seoul 136-713. ]
• Min-Kyu OH [ Dept. of Chemical &Biological Engineering, Korea University, Seoul, 136-701. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576