Earticle

초록

영어

A sulfated polysaccharide, Fucoidan has been well studied as the anti-oxidant, anti-viral, anti- tumor and anti-coagulant, etc... We have proceeded with a aim to explore this molecule as an anti-melanogenic agent. It has been found, there was a significant reduction in melanin biosynthesis in melan-a cell, while treated with fucoidan, In vitro. The results showed that the concentration up to 100 ㎍/㎖, can reduces the melanin level approximately 40+5%, without any cell toxicity. A significant decrease in expression of cellular tyrosinase was observed. Means this molecule have some down regulatory role in expression of tyrosinase enzyme. Thus elucidation of the mechanism of action must be explored, which is poorly understood. In the present study, we have tried to evaluate the effect of fucoidan on the expression of major proteins, influencing the melanin synthesis. It is well known that melanin synthesis involves a series of reaction catalyzed by specific gene products. Therefore, we have targeted the key proteins like TYR, TRP-1, TRP-2, MITF, ERK, CREB etc. These present studies are important in terms of mechanism elucidation and for design and developing a fucoidan based safer cosmetics.

키워드

저자

• JungEun KIM [ Dept. of Biological Engineering, Inha University, Incheon. ]
• V.K. MORYA [ Dept. of Biological Engineering, Inha University, Incheon. ]
• Hyang-Bok LEE [ Dept. of Biological Engineering, Inha University, Incheon. ]
• Dung Hoang NGUYEN [ Dept. of Biological Engineering, Inha University, Incheon. ]
• SangJoo PARK [ Dept. of Biological Engineering, Inha University, Incheon. ]
• InSeo CHOI [ Dept. of Biological Engineering, Inha University, Incheon. ]
• Eun-Ki KIM [ Dept. of Biological Engineering, Inha University, Incheon. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576