Earticle

초록

영어

To treat hyperpigmentating diseases such as such as melasma and lentigines, a number of melanogenesis inhibitors have been screened for their effectiveness in reducing melanin but none have shown to be completely satisfactory. Pink eyed dilution protein (P-protein) is a melanogenogenic protein and plays a critical role in cellular melanogenesis. The present study is aimed to develop an alternative molecular approach using P-protein small interfering RNA (siRNA) to control melanogenesis in the melan-a melanocyte. It has been observed the both P-protien and mRNA level were significantly lowered by the siRNA treatment. P-protein siRNA also suppressed melanin synthesis without any cytotoxicity in the melan-a melanocyte cells. These results suggest that molecular approaches using siRNA targeting P-protein may a novel approach for the control of the melanogenesis in a safer way.

키워드

저자

• Dung HOANG NGUYEN [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]
• Vivek MORYA [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]
• Hyang-Bok LEE [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]
• Jung-Eun KIM [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]
• SangJoo PARK [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]
• Melanie AYUNGO [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]
• Eun-Ki KIM [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576