Earticle

초록

영어

The present studies have been carried out to evaluate the variation of three ethnic groups (Malaysian, Korean and Vietnamese) in Asian stratum corneum lipid profile. Stratum corneum lipid plays a predominant role in maintaining the water barrier of the skin. In order to understand the biological variation in the levels and composition of cholesterol, fatty acids and ceramides, stratum corneum lipids collected from solvent extraction from inner forearm of three ethnic groups were analysed. In addition we studied the correlation of stratum corneum lipid composition on the skin barrier function and epidermal thickness from the same area. Stratum corneum lipids are separated into three main lipid classes: cholesterol, fatty acid and ceramide. In this study, a salicylic acid column chromatography (SACC) method was successfully developed to separate the three lipid classes from stratum corneum lipid samples. The main lipid species were quantified using high performance thin-layer chromatography (HPTLC) and individual fatty acids using gas chromatography (GC). Our finding demonstrated significantly lower amounts of total stratum corneum lipid and level of ceramide composition in Malaysian subjects compared to Korean and Vietnamese. In parallel, Malaysians were placed in the third position for skin barrier function, expressed in TEWL. In contrast, Malaysians had the thickest epidermis as measured by confocal reflectance microscopy (CRM). This pilot study suggests that among the Asian subject itself manifest skin conditions differently. Therefore, the individual fatty acid profile was carried out to provide valuable information on skin biological variations among the three ethnic groups.

키워드

저자

• Rosnani HASHAM [ Dept. of chemical and biochemical engineering, Dongguk university, Seoul, 100-175. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576