Earticle

초록

영어

Ionic liquids(ILs) have many advantages like low-volatility, Nonflammability and Electrical conductivity, so the ILs are widely used in various fields including extraction, sensors, refining materials and chemical catalysis. Although ILs are called to green solvent due to their high recovery rate, micro-spill to the environment is inevitable. In this work, we study Shewanella oneidensis MR-1 to elucidate the toxic mechanism of ILs to resolve problem. We assume that the major cause of cell death is the perturbation of cell membranes, resulting in the physical disruption of its structure and the interferences of signaling pathway. To further study the membrane interaction of ILs, we use a model sell membrane composed of amphiphilic biopolymer, polydiacetylen e(PDA). In particular well ordered PCDA monomers in a liposome are crosslinked by 1,4-addition by UV, showing red color with the naked eyes. To ensure the membrane perturbation of ILs we employ other analytical tools including differential scanning calorimetry(DSC) and particle size analyzer. We expect that our work will provide more comprehensive understandings of the effects of ILs to biological organisms, particularly in cells at a molecular level.

키워드

저자

• Hyunil RYU [ Department of Biological Engineering, Inha University, Younghyun-Dong, Incheon, 402-751. ]
• Seunghwan JEONG [ Department of Biological Engineering, Inha University, Younghyun-Dong, Incheon, 402-751. ]
• Sang-Hyun HAN [ Department of Biological Engineering, Inha University, Younghyun-Dong, Incheon, 402-751. ]
• Sung Ho HA [ Department of Biological Engineering, Inha University, Younghyun-Dong, Incheon, 402-751. ]
• Yoon-Mo KOO [ Department of Biological Engineering, Inha University, Younghyun-Dong, Incheon, 402-751. ]
• Jae-Seong SO [ Department of Biological Engineering, Inha University, Younghyun-Dong, Incheon, 402-751. ]
• Tae-Joon JEON [ Department of Biological Engineering, Inha University, Younghyun-Dong, Incheon, 402-751. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576