Earticle

초록

영어

Inflammation is known for complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective reaction by the organism to remove the injurious stimuli and to initiate the healing process. In other view-point, long lasting of inflammation destroys tissue and organism that cause disease. Therefore, it is recognized important issue that detection of inflammation on living cell in the initial stage. Previous study, we found out bradykinin 1 receptor is one of the proper biomarker for cell inflammation. In this study, we set up chip-based cell-inflammation imaging system through investigation of bradykinin 1 receptor and modified bradykinin peptide. The channel for live cell imaging which made of PDMS wall and quartz panel shows great image difference between normal cells and inflammated cells. The image analyze system by peptide probe would be an important basis for developing cell-inflammation analysis system for efficient high-throughput screening of anti-inflammation drug.

키워드

저자

• Seung Pil PACK [ Dept. of Biotechnology and Bioinformatics, Korea University, Chungnam, 339-700. ]
• Ki Baek YEO [ Dept. of Biotechnology and Bioinformatics, Korea University, Chungnam, 339-700. ]
• Eui Kyoung JANG [ Dept. of Biotechnology and Bioinformatics, Korea University, Chungnam, 339-700. ]
• Ki Ha MIN [ Dept. of Biotechnology and Bioinformatics, Korea University, Chungnam, 339-700. ]
• Mi-Ran KI [ Dept. of Biotechnology and Bioinformatics, Korea University, Chungnam, 339-700. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576