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포스터 발표 : 세포치료 및 조직공학

Development of Three-dimensional Culture System for Periosteum-derived Progenitor Cells

첫 페이지 보기
  • 발행기관
    한국생물공학회 바로가기
  • 간행물
    한국생물공학회 학술대회 바로가기
  • 통권
    2012 춘계학술대회 및 국제심포지움 (2012.04)바로가기
  • 페이지
    pp.233-233
  • 저자
    Hyun-Myoung CHA, Joon-Serk SEO, Kyung-Ho KANG, Eun-Sun KO, Min-Ho CHOI, Ji-Sung PARK, Hyo-Young JEON, Dong-Il KIM
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A174798

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원문정보

초록

영어
Cell therapy has the potential for providing new way of clinical treatments. Mesenchymal stem cells (MSCs) are important tools for cell therapy because of their high proliferation and differentiation ability as well as immunosuppressive properties. MSCs are commonly cultured as monolayers, but there are indications that they lose cell-specific properties with multiplication in vitro. In addition, it was reported that the culture of MSCs as a spheroid form in a short period improved their therapeutic potential by increased expression of genes such as CXCR4 to promote adhesion to endothelial cells or IL-24 that has tumor suppressing properties. In this study, we developed a new three-dimensional (3D) culture system for periosteum-derived progenitor cells (PDPCs) which are one of diverse MSCs. The spheroid formation of PDPCs was induced by using a rotation platform. The spheres was found to maintain self-renewal ability. After 3D culture, the spheres expressed MSCs-specific surface markers and stem-cell-associated genes. In conclusion, an economical culture system could be developed. This system can be utilized for the scale-up 3D culture of the PDPCs.

키워드

Mesenchymal stem cell Three-dimensional culture periosteum-derived progenitor cell

저자

  • Hyun-Myoung CHA [ Department of Biological Engineering, Inha University, Incheon 402-751, Korea. ]
  • Joon-Serk SEO [ Department of Biological Engineering, Inha University, Incheon 402-751, Korea. ]
  • Kyung-Ho KANG [ Department of Biological Engineering, Inha University, Incheon 402-751, Korea. ]
  • Eun-Sun KO [ Department of Biological Engineering, Inha University, Incheon 402-751, Korea. ]
  • Min-Ho CHOI [ Department of Biological Engineering, Inha University, Incheon 402-751, Korea. ]
  • Ji-Sung PARK [ Department of Biological Engineering, Inha University, Incheon 402-751, Korea. ]
  • Hyo-Young JEON [ Department of Biological Engineering, Inha University, Incheon 402-751, Korea. ]
  • Dong-Il KIM [ Department of Biological Engineering, Inha University, Incheon 402-751, Korea. ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
  • 설립연도
    1984
  • 분야
    공학>생물공학
  • 소개
    이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동

간행물

  • 간행물명
    한국생물공학회 학술대회
  • 간기
    반년간
  • 수록기간
    1985~2013
  • 십진분류
    KDC 476 DDC 576

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