Earticle

초록

영어

It is necessary and important to ferment Saururus chinensis(SC)massively with the effective specific microorganism for the short term fermenting period. Useful bacteria were identified and isolated from SC extract produced by the conventional fermentation process. It contains the highest number of bacillus species. Although many previous studies on SC were performed, most of them were based on the non-fermented SC. There was scarcely any study on the comparitive evaluation of fermented SC and non-fermented SC. This study is the first case, especially on the Bacillus subtilis 168-fermented SC. Optimum temperature of fermented Saururus chinensis extract(FSC) was 40°C and optimum time was 34 hour. The purpose of this study was to investigate the effect of FSC and non-fermented Saururus chinensis extract(NFSC). TLC and HPLC showed the increase of rutin and quercetin due to the fermentation. Furthermore, FSC had more effect than NFSC in free radical scavenging activity, anti-autooxidative activity and cell viability of prostate cancer cell in vitro. The high scavenging abilities of DPPH, OH-, O2 - were observed. Also FSC showed the inhibition effect on NO rate. This anti-inflammatory activities were further supported by the inhibition of iNOS and COX-2 expression. These results showed that decrease in unit activity of iNOS and COX-2 were principally due to inhibition of iNOS and COX-2 protein expression, which accounts for the decreased accumulation of nitrite in cells treated with FSC and NFSC. These results demonstrated that FSC could be useful as an anti-inflammatory and anti-oxidative functional ingredient.

키워드

저자

• Bae Jin HA [ Department of Pharmaceutical Engineering,Silla University, Busan, 614-735. ]
• Ryun Hee KWON [ Department of Pharmaceutical Engineering,Silla University, Busan, 614-735. ]

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간행물

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• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576