Calcium is a key mineral that affects especially the quality of life as human age. The bioavailability of calcium is currently one of the most important topics in nutrition research and is correlated with gastrointestinal solubility. We applied the poly-γ-glutamic acid, an edible and biodegradable polymer, in order to increase the solubility of calcium. The result showed that γ-PGA enhanced calcium absorption from the small intestine when administered to rat. In vitro, the solubility of calcium was increased in a dose- and molecular weight-dependant manner. And we confirmed the effect of PGA on the calcium uptake in the small intestine using rats as an animal model system. γ-PGA had been approved as functional food ingredient by Korean Food and Drug Administration (KFDA); its health claim is “the promotion of calcium absorption”. Useful dosage for calcium absorption is suggested to 60~70 mg per day. These studies may suggest more effective applications of calcium supply as the dietary supplements. [This work was supported by a grant from the Next-Generation BioGreen 21 Program (No. PJ0083272011)]
키워드
poly-gamma-glutamic acidbioavailability of calciumhealth functional food
저자
Jae-Chul CHOI [ BioLeaders Corporation, Daejeon, Korea, Department of Advanced Fermentation Fusion Science &Technology, Kookmin University, Seoul, Korea. ]
Sung-Jin LEE [ BioLeaders Corporation, Daejeon, Korea. ]
Kyung-Soo HAHM [ BioLeaders Corporation, Daejeon, Korea. ]
Moon-Hee SUNG [ BioLeaders Corporation, Daejeon, Korea, Department of Advanced Fermentation Fusion Science &Technology, Kookmin University, Seoul, Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동