Earticle

초록

영어

The derivatives of Monascus pigment, which have beneficial effects including reduction of body weight gain, decrease of total cholesterol and triglyceride contents, and increase of HDL-cholesterol level and HTR value were produced by Monascus fermentation. L-Trp and L-Lue-OEt derivatives were selected to investigate anti-obesity effects on mice. High fat diets (HFDs) supplemented with two derivatives were fed to mice groups. Compared to the HFD group, the average body weight gain of HFD-pigment groups was decreased by 13.6-50.9%, while the HDL-cholesterol and the HTR value in the serum were increased by 64.8-66.4% and 73.8-81.7%. The total cholesterol and triglyceride levels in the mice liver were reduced by 9.7-39.9% and 17.9-22.4%, respectively. The results showed a possibility that functional food ingredients can be developed from the various derivatives of monascus pigment, which are a GRAS (generally recognized as safe) compound and can reduce obesity.

키워드

저자

• Deokyeong CHOE [ Dept. of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749. ]
• Heeyoung JANG [ Dept. of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749. ]
• Soomin SONG [ Dept. of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749. ]
• Jong Hoon KIM [ Dept. of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749. ]
• Chul Soo SHIN [ Dept. of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576