Hee-Young AHN, Jae-Hong LEE, Jae-Young CHA, Young-Su CHO
언어
영어(ENG)
URL
https://www.earticle.net/Article/A174686
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원문정보
초록
영어
Current study was to investigate the potential effects of Monascus purpureus-fermented Angelica gigas Radix(FAG) at the 5% (w/w) levels against hepatotoxicity and antihyperlipidemic activity in Sprague-Dawley rats, which was intoxicated with 30% (v/v) alcohol for 4 weeks. Administration of FAG markedly prevented alcohol-induced elevation of the activities of serum AST, γ-GTP and LDH, and these reduced levels reached to that of the normal rats. Interestingly, FAG administration drastically increased both hepatic alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities in comparison to AG, thus FAG would be more effective in the reduction of blood alcohol and acetaldehyde. In the lipid profiles, the contents of serum total lipid, total cholesterol (TC), triglycerides (TG), and nonestrified fatty acids (NEFA) and hepatic TG were significantly elevated in the ethanol-induced rats. Supplementation of FAG improved the antioxidant status by decreasing the levels of TBARS and altering the lipid profiles to near normal. Thus, the findings of the present study indicated a significant hepatotoxicity and antihyperlipidemic activity of Monascus purpureus-fermented Angelica gigas Radix against ethanol-induced toxicity.
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동