Byul-Nim AHN, Jung-Ae KIM, Chang-Suk KONG, Se-Kwon KIM
언어
영어(ENG)
URL
https://www.earticle.net/Article/A174379
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원문정보
초록
영어
Ultraviolet-B (UVB) irradiation causes DNA damage and induces increase of matrix metalloproteinases (MMPs) in keratinocyte cells. Libanoridin is a natural product isolated from Corydalis heterocarpa which has recently been found to be effective antioxidant and anti-inflmmation. In this study, we assessed the effect of libanoridin aggainst UVB-induced damage using human keratinocyte (HaCaT) cells. In the results observed that libanoridin inhibited cell cytotoxicity and DNA damage due to 40 mJ/cm2 UVB exposure. Moreover, type IV collaganases MMP-2,-9 expression were decreased and MMP tissue inhibitor-1 (TIMP-1) decrease was inhibited followed by libanoridin treatment. In additionally we indicated that UVB-induced activation of phosphorylation of three MAPKase JNK, ERK, p38 and AP-1 transcription factor were decreased with libanoridin treatment. In conclusion, this study demonstrates that libanoridin has abilities to UVB induced cellular damage via MAPK and AP-1 signalling pathways, therefore, libanoridin may be used as an effetive natural compound on skin damage due to UVB exposure.
키워드
CoumarineUVB exposureDNA damageMMP
저자
Byul-Nim AHN [ Department of Chemistry, Pukyoung National University, Busan 608-737, Republic of Korea. ]
Jung-Ae KIM [ Marine Bioprocess Research Center, Pukyoung National University, Busan 608-737, Republic of Korea. ]
Chang-Suk KONG [ Department of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 617-736, Republic of Korea. ]
Se-Kwon KIM [ Department of Chemistry and Marine Bioprocess Research Center , Pukyoung National University, Busan 608-737, Republic of Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동