Earticle

초록

영어

Undaria pinnatipida including physiologically active substances such as alginate and iodine has been known for health functional food in Korea. Various physiologically active substances isolated from Undaria pinnatipida were investigated to reduce obesity causing adult diseases. In this study, U. pinnatipida harvested in Korean coast was used for the substances by the extractions using hot water, ethanol and methanol. All samples were lyophilized after extraction. Accumulation of triglyceride in mature adipocyte was determined using ORO staining. Cell toxicity of the preadipocyte was determined by MTT assay. Various concentrations of extracts with 0, 50, 100, 150, 200 and 250 ㎍/ml dissolved in DMSO were added to differentiation medium of 3T3-L1. Hot water extract (250 ㎍/ml) did not show cell toxicity at the viability of 82% in 3T3-L1. However, extracts by ethanol (150 ㎍/ml) and methanol (150 ㎍/ml) showed cell toxicity with the cell viability less than 28%. Triglyceride accumulation of the adipocyte treated the extract by hot water was effective to the anti-obesity of 40% comparing to the control cell.

키워드

저자

• Hyejin KIM [ Dept. of Biotechnology, Pukyong National University. ]
• Chang-Han KANG [ Dept. of Biotechnology, Pukyong National University. ]
• Sung-Koo KIM [ Dept. of Biotechnology, Pukyong National University. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576