Earticle

초록

영어

Today a number of nanoparticles are manufactured for clinical and medicinal purposes through conjugating with drugs or bio-molecules such as DNA, RNA, and peptides. There are three distinct ways to deliver nanoparticles into animal and human bodies: injection, feeding, and transdermal administration. In this study, we fabricated biodegradable polymeric microneedle arrays containing nanoparticles for the efficient delivery of functional nanoparticle complexes through the skin. Nanoparticle-conjugated microneedle arrays were manufactured through three steps. First, PDMS (polydimethylsiloxane) molds for needles were casted out using silicon wafer. Second, microneedles were fabricated by curing melted agarose in the mold together with nanoparticles. Third, nanoparticles were separated and arrayed by their sizes using electrophoresis. These nanoparticle-conjugated microneedles have a great potential for an alternative method to deliver cosmetic or pharmaceutical materials into human skin locally without professional procedures and pain.

키워드

저자

• Yun Jeong CHA [ Department of Food and Nutrition, Myongji University, Yongin, Kyonggi 449-728. ]
• Hyun Ho LEE [ Department of Chemical Engineering, Myongji University, Yongin, Kyonggi 449-728. ]
• Shin Sik CHOI [ Department of Food and Nutrition, Myongji University, Yongin, Kyonggi 449-728. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576