Seongwoo YANG, Byul-Nim AHN, Jung-Ae KIM, Se-Kwon KIM
언어
영어(ENG)
URL
https://www.earticle.net/Article/A174365
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원문정보
초록
영어
Marine brown algae are rich in phlorotannins which have various biological functions such as antioxidant, anti-aging and skin whitening. In this study, phlorotannins were isolated from the marine brown alga and their skin whitening effect on melanoma cells was evaluated by measuring tyrosinase inhibition. The result showed that phlorotannins were inhibited tyrosinase with an IC50 of 200 μM and it was more effective than arbutin without any significant cytotoxicity in melanoma cells. Furthermore, phlorotannins contents in marine brown alga were analyzed by reverse-phased high performance liquid chromatography (HPLC) technique. The HPLC method for determination of phlorotannins from the extracts of marine brown alga was validated for linearity, precision, accuracy, limit of detection (LOD) and limits of quantitation (LOQ). The contents of phlorotannins were calculated by linear calibration curves of standard compounds. These results suggest that phlorotannins have great potential to be further developed as a pharmaceutical or cosmetic agent for use in dermatological disorders associated with melanin.
키워드
Marine brown algaphlorotanninskin whitening
저자
Seongwoo YANG [ Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea. ]
Byul-Nim AHN [ Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea. ]
Jung-Ae KIM [ Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea. ]
Se-Kwon KIM [ Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea, Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동