Young-Sang KIM, Kyong-Hwa KANG, BoMi RYU, Se-Kwon KIM
언어
영어(ENG)
URL
https://www.earticle.net/Article/A174350
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원문정보
초록
영어
Marine microalgae produce large array of metabolic products. Therefore, marine microalgae is used in different fields of application including nutraceutical, pharmaceuticals and cosmetic ingredient. However, there are less reports in use of microalgae on isolating active metabolites. So, this study has focused on investigating the apoptosis inductive effects of active compound, stigmasterol isolate from marine microalgae Navicula incerta extracts. There are several reports on anti-cancer effects of plant sterols on breast cancer and prostate cancer, but no reports on liver cancer. Thus, we investigated the apoptosis inductive effects of stigmasterol on hepatocarcinoma HepG2 cells. According to the results obtained stigmasterol induce the apoptosis on HepG2 cell by down regulating Bcl-2 and by upregulating caspase-8, 9 and FASL. In conclusion, we can suggest that the stigmasterol isolated from marine microalgae shows potent apoptosis inductive effects and could be developed as a anti-cancer therapeutic against liver cancer.
키워드
Navicula incertaphytosterolapoptosisHepG2 cell
저자
Young-Sang KIM [ Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea. ]
Kyong-Hwa KANG [ Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea. ]
BoMi RYU [ Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea. ]
Se-Kwon KIM [ Department of Chemistry, Pukyong National University, Busan 608-737, Republic of KoreabMarine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of KoreabMarine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동