Earticle

초록

영어

Recent cancer therapies have developed multi-functional modulated medications with enhanced therapeutic efficacy and safety.1,2 Inspired by these trends, we demonstrate a novel anti-cancer therapeutics composed of diversified medicinal subdivisions containing both DNA/RNA/doxorubicin cassettes and gold nanorods. It enables to exhibit a chemotherapy and a photothermal therapy at the same time, Owing to the synergic effects, as compared with traditional anti-cancer methods based on a singlet anti-cancer strategy, the improved therapeutic efficacy against a PSMA expressing prostate cancer is observed in in vitro and even in vivo. The therapeutic efficacy is regulated depending on the concentration of gold nanorods and doxorubicin incorporated DNA/RNA nanostructures. These system mediate dramatical regression of prostate tumors in athymic mice, relative to control groups including free AuNRs and doxorubicin alone. It may be due to several therapeutic factors representing a PSMA-specific A10 aptamer-based active targeting, a doxorubicin-induced gene transcription inhibition, and a gold nanorods-derived localizing thermal ablation. These studies demonstrate that the selective replacement of other nucleic acids specific and active drugs on the therapeutics may have it easily applied to various infectious diseases.

키워드

저자

• A Ra KIM [ Dept. of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, 440-760. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576