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글로벌코스메틱연구개발사업단 성과발표회 II: 융합기반기술 개발연구 성과발표, 좌장 : 조완구 (전주대학교)

Three Dimensional Skin Model and Regulation of Interfollicular Epidermal Stem Cell

첫 페이지 보기
  • 발행기관
    한국생물공학회 바로가기
  • 간행물
    한국생물공학회 학술대회 바로가기
  • 통권
    2012 춘계학술대회 및 국제심포지움 (2012.04)바로가기
  • 페이지
    pp.123-123
  • 저자
    Kyoung-Chan PARK, Hye-Ryung CHOI, Seung-Hye YANG, Dong-Seok KIM
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A174312

※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.

원문정보

초록

영어
Keratinocytes can be divided into stem cells, transit amplifying cells, and postmitotic differentiating cells. Epidermal stem cells can contribute to the maintenance of the epidermis via their self-renewing ability. Recently, it was suggested that cell-ECM interactions influence these findings. Thus, strategies for manipulating cell-ECM interactions hold promise in controlling skin disease or preventing aging effects. Epidermal cells are surrounded by neighboring cells and tissues. Thus, it is possible that epidermal cells are under the control of surrounding environment. Previously, we reported the effects of dermal sheath cells (DSC) on the maintenance of stemness of interfollicular epidermal stem cells and recovering effects on basement membrane. In that study, we found that IGFBP-2 is a major factor from DSCs which affects epidermal regenerative capacity of skin. Thus, we proposed stem cell activation as a new concept for the development of cosmetic or therapeutic agents. There are diverse cells in the skin and fibroblasts are also an essential component of skin. Thus, it can be hypothesized that fibroblasts also may affect the stemness of epithelial cells. The epidermal regenerative effect of both neonatal and child fibroblasts were compared in a skin equivalent model. These findings clearly showed that stemness of interfollicular stem cells can be regulated by surrounding factors of skin and stem cell activator can be useful in controlling skin aging and disease. Importantly, skin equivalent needs to be consistent to be used as a model for in vitro model. In this study, the use of Cervi Cornus Colla will be presented which greatly improve the consistency of skin equivalent to be used in experiment.

저자

  • Kyoung-Chan PARK [ Department of Dermatology, Bundang Seoul National University College of Medicine/Department of Biochemistry, Chung-Ang University College of Medicine. ]
  • Hye-Ryung CHOI [ Department of Dermatology, Bundang Seoul National University College of Medicine/Department of Biochemistry, Chung-Ang University College of Medicine. ]
  • Seung-Hye YANG [ Department of Dermatology, Bundang Seoul National University College of Medicine/Department of Biochemistry, Chung-Ang University College of Medicine. ]
  • Dong-Seok KIM [ Department of Dermatology, Bundang Seoul National University College of Medicine/Department of Biochemistry, Chung-Ang University College of Medicine. ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
  • 설립연도
    1984
  • 분야
    공학>생물공학
  • 소개
    이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동

간행물

  • 간행물명
    한국생물공학회 학술대회
  • 간기
    반년간
  • 수록기간
    1985~2013
  • 십진분류
    KDC 476 DDC 576

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