Soo-Hong LEE, Byung-Hyun CHA, Jong Chan AHN, Jae-Hwan KIM
언어
영어(ENG)
URL
https://www.earticle.net/Article/A174092
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원문정보
초록
영어
Stem cell therapy has been developing rapidly as a potential cure for repairing or regenerating the functions of diseased organs and tissues. Adipose-derived stromal cells (ASCs) are an attractive cell source for stem cell therapy because they can be isolated easily from fat tissue in significant numbers and exhibit multiple differentiation potential under appropriate in vitro culture conditions. However, ASCs derived from individual donors can show wide variations in differentiation potential. In addition, the regulatory mechanisms underlying stem cell differentiation remain unclear. Bone morphogenic protein 2 (BMP-2) is an important signal for up-regulation of osteogenesis and chondrogenesis of stem cells. SRY-related HMG-box gene 9 (SOX-9) has also been reported as one of the key transcription factors for chondrogenesis. Meanwhile, transforming growth factor β (TGFβ) is a well-known ASC chondrogenic differentiation factor that stimulates ASC signaling pathways by activating transmembrane type I and type II receptors. We hypothesized that co-delivery of those genes would result in improved efficiency of recovery of normal chondrogenic properties in dedifferentiated chondrocytes.
키워드
Cartilage tissue regenerationAdipose-derived stromal cellsCo-delivery of genes
저자
Soo-Hong LEE [ Department of Biomedical Science, CHA University, Gyunggi-do 463-840. ]
Byung-Hyun CHA [ Department of Biomedical Science, CHA University, Gyunggi-do 463-840. ]
Jong Chan AHN [ Department of Biomedical Science, CHA University, Gyunggi-do 463-840. ]
Jae-Hwan KIM [ Department of Biomedical Science, CHA University, Gyunggi-do 463-840. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동