Earticle

초록

영어

Zinc phthalocyanine (ZnPc) is one of the most promising next generation photosensitizers that can replace FDA-approved porphyrin-based photosensitizers for the photodynamic cancer therapy (PDT), due to its favorable photophysical, photochemical properties, and strong absorption in the spectral range of 600-900 nm that guarantees maximum tissue penetration. One of the most important hurdles that ZnPc faces for the facile application in biological environments is its low solubility (or dispersibility) in water. So far, the solubility increase has been sought by introducing hydrophilic moieties into the molecular backbones of ZnPc and porphyrin-based photodynamic agents. In this presentation, I will introduce an unexpectedly increased water dispersibility of ZnPc when ZnPc molecules are self-crystallized into one-dimensional nanowires. The ZnPC nanowires have been synthesized by vaporization-condensation-recrystallization (VCR) process, a sort of solid-vapor-solid process at 550 oC using ZnPc powder as a precursor. The increased water dispersibility of ZnPc NW is attributed to the increased available water-binding sites in ZnPc molecules present in a form NW crystal structure. Different from ZnPc powder (b form) that has a strong interaction between ZnPc rings through Zn(II)-N interactions, a form ZnPc NW has a weak inter-ring interaction because a top ZnPc ring is off-staggered to a bottom ZnPc ring, so that the Zn(II) ions and all of skeleton N atoms are ligation-free to accommodate more water molecules to interact. The water solution of ZnPc NW has been tested for photodynamic cancer therapy. Interestingly, the ZnPc NW aqueous solution shows dual photodynamic and photothermal properties, by which tumor cells could be destroyed more efficiently. Such dual property-driven therapeutic effects have been examined by both in vitro and in vivo experiments. The results reveal that ZnPc NWs are internalized well into the KB tumor cells, and eradicates the tumor cells very efficiently upon the irradiation of NIR (808 nm) light for 3 min.

키워드

저자

• Hee Cheul CHOI [ Department of Chemistry and Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH). ]
• Hye Kyung MOON [ Department of Chemistry and Division of Advanced Materials Science, Pohang University of Science and Technology (POSTECH). ]

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발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576